Regeneration has fascinated philosophers and scientists since the beginning of history. The wide but uneven distribution of regenerative capacities among multicellular organisms is puzzling, and the permissive/inhibitory mechanisms regulating this attribute in animals remain a mystery. The way to do that is to develop a conversation with the body. We need to learn to speak the body’s language.To switch on processes we investigate how to do when we were a fetus. Like adults we conserve stem cells.
The development of new therapies for chronic disease and injury by funding stem cell research programs and regenerative medicine under the highest ethical and medical standards for the discovery and development of cures, therapies, diagnostics and research technologies to relieve human suffering from chronic disease and injury.
Another goal is to make stem cells safe and effective for regenerative medicine therapies for diseases such as Diabetes, Parkinson’s Disease, Alzheimer’s Disease, Blindness, Deafness, Arthritis, Heart Disease, Liver Disease, Huntington’s Disease, Cancer and many others.
More About Stem Cells For Osteoarthritis <–info
Can repair stem cells treat my disease?
This list was pulled from http://www.donmargolis.com the only blog that organizes all of it’s articles based on diseases that are treatable with repair stem cells. Click below to read actual articles about patients who have received stem cell treatments for over 100 diseases. If you don’t see your condition listed here, feel free to contact me for more information. Top Stem Cell Treatment Blog <–more info
Foster City woman races to find stem cell donor for cousin with leukemia <–more info
Diseases NOW Being Treated by Stem Cells.
The Repair Stem Cell Institute has compiled a comprehensive list of Repair Stem Cell doctors, physicians, and researchers who are treating patients now. There is no need to wait 5-10 years for USA Repair Stem Cell clinical trials to be completed or 10-20 years for embryonic derived treatments. Cutting-edge Repair Stem Cell companies and physicians are giving their patients a better quality of life NOW – patients who, at home, are told that “their disease is incurable” and “there is nothing more you can do.”
For detailed information visit:
The Don Margolis Blog: Adult Stem Cells – The Greatest Medicine Known to Humankind <–press here
Treating Genetic Disorders Before Birth
Fortifying the fetus: By studying the immune systems of 14-day-old mouse embryos (shown here in an ultrasound), researchers have shown that genetic blood disorders might be treatable before birth. Credit: Journal of Clinical Investigation
Physicians may one day be able to treat genetic blood diseases before a child is even born. In a study of mice that was published this week in the Journal of Clinical Investigation, researchers at the University of California, San Francisco, have found that transplanting a mother’s own stem cells into her fetus populates its bone marrow with healthy cells while avoiding immune rejection.
If the findings hold true in humans, stem-cell transplants from mother to fetus could prime the fetus for a bone-marrow transplant from its mother—or a donor that is tissue-matched to the mother—after birth. Diseases such as sickle cell anemia and beta thalassemia result from abnormal red blood cells and can be treated with bone-marrow transplants. But it’s not always possible to find a match. And standard bone-marrow transplants, even between tissue-matched donors, must be followed with a lengthy course of immunosuppressive drugs. Scientists theorize that bone-marrow transplants performed when a fetus is still developing would override this problem. They suspect that the fetus’s immature immune system could be tricked into adopting those foreign cells and recognizing them as its own. “The fetus is wired to tolerate cells—when it encounters cells from mom, it tolerates them,” says Tippi MacKenzie, the pediatric surgeon at UCSF who led the new research.
Researchers are working on transplanting stem cells in utero. <–more info
Rush for patents is choking US stem cell research
Cures for paralysis, blindness and diabetes could all be in reach with embryonic stem cell research, but the pursuit of medical progress is being choked by the US rush to secure patents, experts say. Scientists are busily filing for legal patents that give them exclusive intellectual property rights for each discovery they make in the hopes that one day, one will lead to a blockbuster cure and big cash for those who devised it.
But the process means that US scientists — already stymied by years of government funding freezes linked to controversy over the destruction of human embryos — often find themselves blocked because other universities or private companies have already secured exclusive rights. “You just have this complete minefield out there and you know who the victims are? It’s the patients,” said Bob Lanza, chief scientific officer at Advanced Cell Technology, which is researching the use of human embryonic stem cells to halt some forms of blindness.
Stem cell Patents <–more info.
Stem Cells Clinical Trials
Clinical trials often involve patients with specific health conditions who then benefit from receiving otherwise unavailable treatments. In early phases, participants are healthy volunteers who receive financial incentives for their inconvenience. During dosing periods, study subjects typically remain on site at the unit for durations of anything from 1 to 30 nights, occasionally longer, although is not always required. Clinical trials are conducted to allow safety and efficacy data to be collected for health interventions (e.g., drugs, diagnostics, devices, therapy protocols). These trials can take place only after satisfactory information has been gathered on the quality of the non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.
ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial’s purpose, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals. Review the current clinical trials with human stem cells around the world <— more info
Pulled teeth stored for stem cells
Dentists are pulling teeth, then having the stem cells stored in case they’re needed to fight disease.
Naidelys Montoya didn’t wait for her son’s baby teeth to fall out. She took the boy to an oral surgeon to have two of the loose ones extracted. “He was a bit scared,” said Montoya, of Hialeah. “He’s not that brave.” The dentist shipped the teeth in a temperature-controlled steel container to a lab in Massachusetts, where their stem cells will be spun out, frozen to more than 100 degrees below zero and stored — in case her son, Raul Estrada, 6, might need them for a future illness. “I believe in this,” Montoya said. “I did as a precaution against things that could happen in the future.” Montoya and her son have joined a major new medical movement.
Dentist Dr. Jeffrey Blum holds up a molar similar to the one that would be sent to a cryogenics lab in New York City to be frozen and stored.
All Around the world, dentists are extracting baby teeth, wisdom teeth and even healthy adult teeth, and researchers are spinning out stem cells that they believe can be used to regrow lost teeth, someday even to repair damaged bones, hearts, pancreases, muscles and brains.It could put the Tooth Fairy out of business. “These are teeth we’ve been discarding as dental waste,” said Dr. Jeffrey Blum, the Miami Beach oral surgeon who pulled Raul’s teeth. “We might as well get some use out of them.” “I can’t help but feel excitement for their potential use in regenerating different tissues in the human body,” said Dr. Jeremy Mao, director of the Regenerative Medicine Laboratory at Columbia University. Mao also is chief science advisor to StemSave, a New York City company that freezes the stem cells and stores them for later use.
There are concerns. It’s expensive, costing $590 upfront plus $100 a year to store the stem cells from up to four teeth for up to 20 years. It’s speculative, with the first FDA-approved practical use of such stem cells years away. “Every treatment using dental stem cells is still in the clinical testing phase, and won’t be ready for general use for at least five years,” said Art Greco, StemSave’s CEO.
The National Institutes of Health concluded in 2003 that teeth are a rich source of stem cells. Every child has about 20 baby teeth that fall out between ages 6 and 12. Adolescents have wisdom teeth that often are removed between ages 14 and 25 because they crowd the jaw or grow in crookedly.
StemSave. Saving Cells For Life <–more info
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